5-Chloro-2-methoxybenzoyl chloride → HCID 54402741, compound

HRID 1763924Notes

Reaction equation

HRID 1763924 reaction equation
Cl.[CH3:2][C:3](=[CH:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][NH2:18])=[CH:12][CH:11]=1)[C:4]([O:6]CC)=[O:5].[Cl:19][C:20]1[CH:21]=[CH:22][C:23]([O:29][CH3:30])=[C:24]([CH:28]=1)[C:25](Cl)=[O:26]>>[CH3:2][C:3](=[CH:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:16][CH2:17][NH:18][C:25](=[O:26])[C:24]2[CH:28]=[C:20]([Cl:19])[CH:21]=[CH:22][C:23]=2[O:29][CH3:30])=[CH:14][CH:15]=1)[C:4]([OH:6])=[O:5]

Participants

3

Reactant 2

HCID 123841765-Chloro-2-methoxybenzoyl chlorideHCID 70592816HCID 70592816, compound

Product 1

HCID 54402741HCID 54402741, compound

Procedure

By the reaction of ethyl α-methyl-4-(2-aminoethyl)-cinnamate hydrochloride (m.p. 270° C.) with 5-chloro-2-methoxybenzoyl chloride, there is obtained α-methyl-4-[2-(5-chloro-2-methoxybenzamido)-ethyl]-cinnamic acid; m.p. 188°-191° C., after recrystallization from ethanol.

Sources & evidence

ORD record
ord-878a49bed3514e8dbae561a4abfdc2ea
Source dataset
uspto-grants-1978_09
Patent number
US04113871

Reaction notes

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