HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2-methoxybenzoyl chloride → alpha,alpha-Dimethyl-beta-{4-[2-(5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2-methoxybenzoyl chloride | HCID 12384176 | — |
| Reactant | Ethyl alpha,alpha-dimethyl-beta-[4-(2-aminoethyl)-phenyl]-propionate hydrochloride | HCID 20304321 | — |
| Product | alpha,alpha-Dimethyl-beta-{4-[2-(5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-propionic acid | HCID 20304400 | — |
Reaction Steps
By the reaction of ethyl α,α-dimethyl-β-[4-(2-aminoethyl)-phenyl]-propionate hydrochloride with 5-chloro-2-methoxybenzoyl chloride, there is obtained α,α-dimethyl-β-{4-[2-(5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-propionic acid; m.p. 138°-141° C., after recrystallization from ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04113871 |
| Source dataset | uspto-grants-1978_09 |
| ORD ID | ord-e5a380b5576345bdbf6819659eb89504 |
| Source note | uspto-grants-1978_09 |