5-Chloro-2-methoxybenzoyl chloride → HCID 20304405, compound

HRID 1763929Notes

Reaction equation

HRID 1763929 reaction equation
Cl.[NH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([O:19]CC)=[O:18])=[CH:7][CH:6]=1.[Cl:22][C:23]1[CH:24]=[CH:25][C:26]([O:32][CH3:33])=[C:27]([CH:31]=1)[C:28](Cl)=[O:29]>>[Cl:22][C:23]1[CH:24]=[CH:25][C:26]([O:32][CH3:33])=[C:27]([CH:31]=1)[C:28]([NH:2][CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:9][CH:10]=1)=[O:29]

Participants

3

Reactant 2

HCID 123841765-Chloro-2-methoxybenzoyl chlorideHCID 20304456HCID 20304456, compound

Product 1

HCID 20304405HCID 20304405, compound

Procedure

By the reaction of ethyl 6-[4-(2-aminoethyl)-phenyl]-hexane-carboxylate hydrochloride (m.p. 182°-185° C.) with 5-chloro-2-methoxybenzoyl chloride to give 6-{4-[2-(5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-hexane-carboxylic acid; m.p. 36° C., after recrystallisation from toluene.

Sources & evidence

ORD record
ord-cc0ca537f7b944c08f5b46eb95c6094f
Source dataset
uspto-grants-1978_09
Patent number
US04113871

Reaction notes

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