5-Chloro-2-methoxybenzoyl chloride → HCID 20304376, compound

HRID 1763931Notes

Reaction equation

HRID 1763931 reaction equation
Cl.[NH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O:20]CC)=[O:19])=[CH:7][CH:6]=1.[Cl:23][C:24]1[CH:25]=[CH:26][C:27]([O:33][CH3:34])=[C:28]([CH:32]=1)[C:29](Cl)=[O:30]>>[Cl:23][C:24]1[CH:25]=[CH:26][C:27]([O:33][CH3:34])=[C:28]([CH:32]=1)[C:29]([NH:2][CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:9][CH:10]=1)=[O:30]

Participants

3

Reactant 2

HCID 123841765-Chloro-2-methoxybenzoyl chlorideHCID 20304363HCID 20304363, compound

Product 1

HCID 20304376HCID 20304376, compound

Procedure

By the reaction of ethyl 7-[4-(2-aminoethyl)-phenyl]-heptane-carboxylate hydrochloride (m.p. 137°-139° C.) with 5-chloro-2-methoxybenzoyl chloride, there is obtained 7-{4-[2-(5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-heptane-carboxylic acid; m.p. 103°-106° C., after recrystallization from diethyl ether.

Sources & evidence

ORD record
ord-bdb6123d848d4c05a6023dbdc0e65a8f
Source dataset
uspto-grants-1978_09
Patent number
US04113871

Reaction notes

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