5-Chloro-2-methoxybenzoyl chloride → HCID 20304341, compound

HRID 1763933Notes

Reaction equation

HRID 1763933 reaction equation
Cl.[NH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]([O:22]CC)=[O:21])=[CH:7][CH:6]=1.[Cl:25][C:26]1[CH:27]=[CH:28][C:29]([O:35][CH3:36])=[C:30]([CH:34]=1)[C:31](Cl)=[O:32]>>[Cl:25][C:26]1[CH:27]=[CH:28][C:29]([O:35][CH3:36])=[C:30]([CH:34]=1)[C:31]([NH:2][CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]([OH:22])=[O:21])=[CH:9][CH:10]=1)=[O:32]

Participants

3

Reactant 2

HCID 123841765-Chloro-2-methoxybenzoyl chlorideHCID 20304339HCID 20304339, compound

Product 1

HCID 20304341HCID 20304341, compound

Procedure

By the reaction of ethyl 9-[4-(2-aminoethyl)-phenyl]-nonane-carboxylate hydrochloride (m.p. 135°-138° C.) with 5-chloro-2-methoxybenzoyl chloride, there is obtained 9-{4-[2-(5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-nonane-carboxylic acid; m.p. 97°-100° C., after recrystallization from ethyl acetate.

Sources & evidence

ORD record
ord-07d3f85463c049eba7132c302c2f27c4
Source dataset
uspto-grants-1978_09
Patent number
US04113871

Reaction notes

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