HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Dioxide → HCID 54330864, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Dioxide | HCID 280 | — |
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 5-Chloro-N-[2-(4-formylphenyl)ethyl]-2-methoxybenzamide | HCID 20304409 | — |
| Reactant | HCID 54530367 | HCID 54530367 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 54330864 | HCID 54330864 | — |
Reaction Steps
31.75 g. 4-[2-(5-chloro-2-methoxybenzamido)-ethyl]-benzaldehyde (m.p. 115°-116° C.) and 1 ml. piperidine are added to 11.5 g. malonic acid in 100 ml. anhydrous pyridine. The reaction mixture is heated on a waterbath until the evolution of carbon dioxide is finished. After cooling, the reaction mixture is poured on to ice/concentrated hydrochloric acid and the precipitate formed is filtered off with suction, whereafter it is recrystallized from ethanol. There are obtained 23.4 g. (about 65% of theory) 4-[2-(5-chloro-2-methoxybenzamido)-ethyl]-cinnamic acid; m.p. 197°-198° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04113871 |
| Source dataset | uspto-grants-1978_09 |
| ORD ID | ord-453d7a2ec2d94058a44a5ec9071105a9 |
| Source note | uspto-grants-1978_09 |