Benzoyl Peroxide → HCID 12401525, compound

Participants

Reaction Conditions

Reaction Steps

41.85 g of 2-(p-tolyl)-s-triazolo[1,5-a]pyridine (26) are dissolved at 50° C. in 1,200 ml of dry carbon tetrachloride. 37.4 g of N-bromosuccinimide and 1 g of dibenzoyl peroxide are then added and the mixture is warmed gradually to the boil while stirring well and with exposure to a 400 W lamp. The reaction mixture is kept under reflux for 4 hours and is then cooled to 20° C. and the product which has precipitated is filtered off with suction. The succinimide is removed by washing with a large amount of water and the material on the suction filter is dried. This gives 39.2 g (58% of theory) of compound (I) in the form of a pale beige powder with a melting point of 192° to 193° C. After recrystallising twice from toluene, 32.3 g (56.1% of theory) of small, virtually colourless, glossy needles with a melting point of 195.5° to 196° C. are obtained.

Provenance & Evidence