2-Nitropropane → HCID 18357635, compound

Participants

Reaction Conditions

Reaction Steps

115.8 g of 2-nitropropane are introduced at about 30° C. into a solution of 23.13 g of sodium in 2,700 ml of anhydrous ethanol. The mixture is stirred for a further one hour and a solution of 288.1 g of 3-(p-bromomethyl-phenyl)-1,2-benzisoxazole in 350 ml of dimethylformamide is now added. Subsequently, the reaction mixture is warmed to 50° C., then stirred for 20 hours without external warming and finally cooled to -10° C. The product which has precipitated is filtered off with suction, washed with cold methanol and dried. This gives 107.4 g (48.1% of theory) of 3-(p-formylphenyl)-1,2-benzisoxazole in the form of a pale yellow powder with a melting point of 117° to 117.5° C. After recrystallising twice from ligroin, small, virtually colourless, glossy needles are obtained which melt at 117° to 117.5° C.

Provenance & Evidence