Hydrochloric Acid → HCID 178525245, compound

Participants

Reaction Steps

12 ml of a 0.5N aqueous solution of sodium bicarbonate was dissolved in a mixture of 836 mg of the sodium salt of 7-(2-thienylacetamido)cephalosporanic acid, 480 mg of 2-(2-mercapto-1,3,4-triazol-5-yl)acetate and 5 ml of water. The resulting solution was heated to a temperature of 62° to 65° C. for 5.5 hours. After completion of the reaction, 10 ml of ice-water was added to the reaction mixture, and 8 ml of 1N HCl was slowly added thereto under ice-cooling and stirring. The precipitated white mass was filtered and washed with water. Immediately thereafter, the precipitate was pulverized with a sufficient amount of diethyl ether to obtain 810 ml of 7-(2-thienylacetamido)-3-(5-carboxymethyl-1,3,4-triazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid as a white powder.

Provenance & Evidence