Hydrochloric Acid → HCID 70616467, compound

Participants

Reaction Steps

358 mg of the sodium salt of 7-(2-thienylacetamido)-cephalosporanic acid and 256 mg of 3-(2-mercapto-1-phenyl-1,3,4-triazol-5-yl)propionic acid were dissolved in 5 ml of water and 4.12 ml of a 0.5N aqueous solution of sodium bicarbonate. The resulting solution was heated on a water bath at 63° to 65° C. in a nitrogen atmosphere for 4.5 hours. After completion of the reaction, 5 ml of ice-water and 3 ml of 1N HCl were added to the reaction mixture while ice-cooling and stirring to precipitate white crystals, which were then filtered and washed with water. Immediately thereafter, the white crystals were throughly washed with diethyl ether to obtain 440 mg of 7-(2-thienylacetamido)-3-[5-(2-carboxyethyl)-1-phenyl-1,3,4-triazol-2-yl]thiomethyl-3-cephem-4-carboxylic acid (yield, 87.5%).

Provenance & Evidence