HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylethylamine → 3-(N-methyl-N-ethylamino)-1,1-diphenyl-propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylethylamine | HCID 12219 | — |
| Reactant | 1,1-Diphenyl-3-bromopropan-2-ol | HCID 12549067 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(N-methyl-N-ethylamino)-1,1-diphenyl-propan-2-ol | HCID 12549068 | — |
Reaction Steps
Excess N methyl-N-ethylamine was added to a solution of 1,1-diphenyl-3-bromo-propan-2-ol (2g) in ethanol. After 60 hours the solution was evaporated and the residue dissolved in dilute hydrochloric acid and ether. Basificiation of the acid extract and subsequent isolation through ether in the usual manner gave 3-(N-methyl-N- ethylamino)-1,1-diphenyl-propan-2-ol isolated as the hydrochloride (1 25g, 60%), m.p. 159°- 161°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04113972 |
| Source dataset | uspto-grants-1978_09 |
| ORD ID | ord-8d5aa6b214c342539f487f98738b3dce |
| Source note | uspto-grants-1978_09 |