Dimethylamine → 3-Dimethylamino-1,1-diphenyl-propan-2-ol

HRID 1763971Notes

Reaction equation

HRID 1763971 reaction equation
[C:1]1([CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:8]2[O:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:17][NH:18][CH3:19]>C(O)C>[CH3:17][N:18]([CH3:19])[CH2:9][CH:8]([OH:10])[CH:7]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 125490582-(Diphenylmethyl)oxirane

Product 1

HCID 125491223-Dimethylamino-1,1-diphenyl-propan-2-olYield 90%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1,1-Diphenyl-2,3-epoxy-propane prepared as described in Example 21, was further reacted with dimethylamine in ethanol by the procedure described in Example 8 to give 3-dimethylamino-1,1-diphenyl-propan-2-ol (90%) m p 72° - 73°.

Sources & evidence

ORD record
ord-8f16443752e349d0936e6d4b17d79386
Source dataset
uspto-grants-1978_09
Patent number
US04113972

Reaction notes

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