HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Morphine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Codeine | HCID 5284371 | — |
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Solvent | Water | HCID 962 | — |
| Product | Morphine | HCID 5288826 | — |
Reaction Steps
Rapoport et al. (J.A.C.S. 5485 and 5900 73 1951) have claimed a 22% yield of morphine from codeine employing pyridine hydrochloride as the cleavage agent. 1.00g codeine was heated with pyridine hydrochloride for six minutes under nitrogen. The reaction mixture was dissolved in 20ccm water, basified with 10ccm 4N NaOH and extracted with chloroform to yield 0.210g morphine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04114314 |
| Source dataset | uspto-grants-1978_09 |
| ORD ID | ord-14495493d17d402dbe5de0701e4cca38 |
| Source note | uspto-grants-1978_09 |