1H-imidazole-2-carbaldehyde → HCID 23346561, compound

HRID 1764045Notes

Reaction equation

HRID 1764045 reaction equation
[CH3:1][CH:2]1[CH2:6][CH2:5][C:4]2([C:11]([CH3:13])([CH3:12])[CH2:10][CH2:9][CH2:8][C:7]2([CH3:15])[OH:14])[O:3]1.[CH:16](C1NC=CN=1)=[O:17]>>[CH:16]([O:14][C:7]1([CH3:15])[CH2:8][CH2:9][CH2:10][C:11]([CH3:13])([CH3:12])[C:4]21[O:3][CH:2]([CH3:1])[CH2:6][CH2:5]2)=[O:17]

Participants

3

Reactant 2

HCID 249551H-imidazole-2-carbaldehydeHCID 6542853398-90-6

Product 1

HCID 23346561HCID 23346561, compound

Procedure

0.4 g (0.002 M) of 2,6,10,10-tetramethyl-1-oxa-spiro[4.5]decan-6-ol -- isomer A; see Example 1 -- were intimately mixed with 0.5 g (0.005 M) of freshly sublimated formylimidazole and then kept for 2 days at room temperature. The reaction mixture was then extracted with ether and the organic layer washed, dried, evaporated and finally subjected to a fractional distillation to give 0.3 g of a product having b.p. 70°-80°/0.5 Torr and containing 60% of the desired ester. An analytical sample was purified by vapour phase chromatography.

Workup

  1. extractionThe reaction mixture was then extracted with ether
  2. washthe organic layer washed
  3. customdried
  4. customevaporated
  5. distillationfinally subjected to a fractional distillation

Sources & evidence

ORD record
ord-aac398c990874d629dd797e75c4f54eb
Source dataset
uspto-grants-1978_09
Patent number
US04114630

Reaction notes

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