反应详情

42 g of 3-carboxy-2,6-dimethylpyr-4-one is dissolved in 250 ml of methylene chloride. In a second flask, 20 ml of acetyl chloride is cautiously added to 400 ml of methanol. The two solutions are mixed and refluxed for 5 hours. Solid sodium carbonate is added and the solvent removed after a water wash. The residue is distilled (115°-125° at 0.1 mm) to give 40 g of 3-carbomethoxy-2,6-dimethylpyr-4-one as a waxy solid.

1. additionThe two solutions are mixed
2. temperaturerefluxed for 5 hours
3. customthe solvent removed after a water
4. washwash
5. distillationThe residue is distilled (115°-125° at 0.1 mm)