反应详情

16 g of N-(4-chlorophenyl)-3-carbomethoxy-2,6-dimethylpyrid-4-one is suspended in 450 g of 5% aqueous sodium hydroxide and stirred at room temperature for 24 hours. Acidification yields 14.2 g of N-(4-chlorophenyl)-3-carboxy-2,6-dimethylpyrid-4-one (m.p. 260°-61.5° decomp.) which is converted to its sodium salt (m.p. >310°) by neutralization with sodium hydroxide.