Isoindoline → HCID 54255057, compound

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Reaction Steps

The process for the preparation of this compound and its physical properties will be given below. A solution of 5.8 grams of isoindoline in 20 milliliters of methanol is added dropwise to a solution of 3.3 grams of o-ethoxycarbonyloxycinnamyl chloride in 30 milliliters of methanol, and the resulting mixture is stirred for 1 hour at room temperature. After completion of the reaction, the methanol is distilled off, and the residue is extracted with chloroform. The chloroform layer is then purified by silica gel column chromatography and recrystallized from ethanol to obtain 1.2 grams (yield 35%) of N-(o-hydroxycinnamyl)-isoindoline as crystals having a melting point of 161°-163° C. (decomposition).

Provenance & Evidence