Isoindoline → HCID 54026972, compound

Participants

Reaction Steps

The process for the preparation of this compound and its physical properties will be given below. 4.8 grams of m-ethoxycarbonyloxycinnamyl chloride and 7.15 grams of isoindoline are dissolved in 70 milliliters of methanol, and the resulting solution is stirred for 2 hours at room temperature. After completion of the reaction, the methanol is distilled off, and the residue is extracted with benzene. The resulting extract is then purified by silica gel column chromatography and recrystallized from methanol to obtain 1.2 grams (yield 23.9%) of N-(m-hydroxycinnamyl)-isoindoline as crystals having a melting point of 164.5°-165.5° C.

Provenance & Evidence