HCID 54017893, compound → HCID 20306750, compound

Participants

Reaction Steps

A solution of 7.7 g of α-[p-(1-cyclohexenyl)-phenoxy]-n-heptanoic acid ethyl ester in 100 ml of ethanol and 70 ml of 2N sodium hydroxide solution is left to stand overnight at room temperature. The bulk of the solvent is then removed in vacuo, the pH adjusted to 3 by adding concentrated by hydrochloric acid, and the residue extracted with ether. The ether phase is washed until neutral, dried over sodium sulphate and evaporated to dryness in vacuo. The residue is crystallised from petroleum ether to yield the α-[p-(1-cyclo-hexenyl)-phenoxy] -n-heptanoic acid of the formula ##STR4## which melts at 78-80° C.

Provenance & Evidence