Sodium Hydroxide → HCID 20306751, compound

Participants

Reaction Steps

To 38 g of α-[p-(1-cyclohexenyl)-phenoxy]-nonanoic acid ethyl ester in 150 ml of ethanol are added 150 ml of 2N sodium hydroxide solution and the mixture is stirred at room temperature for 2 hours. The ethanol is stripped off in vacuo and the residue partitioned between 2N hydrochloric acid and ether. The organic phase is washed until neutral, dried over sodium sulphate and evaporated to dryness. Distilation of the residue at 0.04 mm yields in the fraction boiling at 173°-176° C the α-[p-(1-cyclohexenyl)-phenoxy]-nonanoic acid of the formula ##STR16## (m.p. 61°-63° C).

Provenance & Evidence