反应详情

温度

50 °C

To a solutuion of 1.6 g of sodium in 100 ml of absolute ethanol are added initially 10 g of p-(1-cyclohexenyl)-phenol in a small amount of absolute ethanol at room temperature under anhydrous conditions and with stirring. 26 Grams of α-bromo-dodecanoic acid ethyl ester are then added dropwise and the mixture is maintained at 50° C for 24 hours. The ethanol is subsequently stripped off in vacuo and the residue is partitioned between water and ice-cold N sodium hydroxide solutuion. The organic phase is washed until neutral, dried over sodium sulphate and concentrated in vacuo. The residue yields the crude α-[p-(1-cyclohexenyl)-phenoxy]-dodecanoic acid ethyl ester of the formula ##STR17## in the form of an oil.

1. customthe residue is partitioned between water and ice-cold N sodium hydroxide solutuion
2. washThe organic phase is washed until neutral,
3. dry with materialdried over sodium sulphate
4. concentrationconcentrated in vacuo