反应详情

100 ml of 2N sodium hydroxide solution are added to 27 g of α-[p-(1-cycloheptenyl)-phenoxy]-undecanoic acid ethyl ester in 150 ml of ethanol and the mixture is stirred for 2 hours at room temperature. The ethanol is removed in vacuo and the residue is partitioned between 2 N hydrochloric acid and ether. The organic phases are washed until neutral, dried over sodium sulphate and concentrated by evaporation in vacuo. Distillation of the residue at 0.04 mm gives α-[p-(1-cycloheptenyl)-phenoxy]-undecanoic acid, of melting point 79°-81° C (from n-hexane), in the fraction boiling at 185°-190° C.

1. customThe ethanol is removed in vacuo
2. customthe residue is partitioned between 2 N hydrochloric acid and ether
3. washThe organic phases are washed until neutral,
4. dry with materialdried over sodium sulphate
5. concentrationconcentrated by evaporation in vacuo
6. distillationDistillation of the residue at 0.04 mm