Thiomorpholine → 6,7-Dimethoxy-2-(thiomorpholin-4-yl)quinazolin-4(3H)-imine

HRID 1764190Notes

Reaction equation

HRID 1764190 reaction equation
Cl[C:2]1[N:11]=[C:10]([NH2:12])[C:9]2[C:4](=[CH:5][C:6]([O:15][CH3:16])=[C:7]([O:13][CH3:14])[CH:8]=2)[N:3]=1.[NH:17]1[CH2:22][CH2:21][S:20][CH2:19][CH2:18]1>ClC1C=CC=CC=1>[CH3:14][O:13][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][C:6]=1[O:15][CH3:16])[N:3]=[C:2]([N:17]1[CH2:22][CH2:21][S:20][CH2:19][CH2:18]1)[N:11]=[C:10]2[NH2:12]

Participants

4

Reactant 2

HCID 67164ThiomorpholineHCID 902352-Chloro-6,7-dimethoxy-4-quinazolinamine

Product 1

HCID 1272896,7-Dimethoxy-2-(thiomorpholin-4-yl)quinazolin-4(3H)-imine

Reagents, catalysts & solvents 1

HCID 7964ChlorobenzeneSolvent

Procedure

A mixture of 8.00 g of 2-chloro-6,7-dimethoxy-4-quinazolinamine and 6.90 g. of thiomorpholine in 80 ml of chlorobenzene was refluxed for 18 hrs. The reaction mixture was cooled to room temperature, and the precipitate was collected. There was deposited 8.00 g (70.2%) of white powder, mp 267°-269°, dec. The product was recrystallized from methanol to give an analytical sample, mp 270°-271°, dec.

Workup

  1. customthe precipitate was collected
  2. customThe product was recrystallized from methanol
  3. customto give an analytical sample, mp 270°-271°, dec.

Sources & evidence

ORD record
ord-9e3e47fbaf174921a2ecbaed989ab1c4
Source dataset
uspto-grants-1978_09
Patent number
US04115565

Reaction notes

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