2-Trifluoromethylphenoxazine → 2-Trifluoromethyl-10-[1-(1-pyrrolin-2-YL)-2-pyrrolin-2-YL]phenoxazine

HRID 1764225Notes

Reaction equation

[F:1][C:2]([F:18])([F:17])[C:3]1[CH:16]=[CH:15][C:14]2[O:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[NH:6][C:5]=2[CH:4]=1.Cl.Cl[C:21]1[N:22]([C:26]2[CH2:30][CH2:29][CH2:28][N:27]=2)[CH2:23][CH2:24][CH:25]=1>>[F:18][C:2]([F:1])([F:17])[C:3]1[CH:16]=[CH:15][C:14]2[O:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[N:6]([C:21]3[N:22]([C:26]4[CH2:30][CH2:29][CH2:28][N:27]=4)[CH2:23][CH2:24][CH:25]=3)[C:5]=2[CH:4]=1

Participants

Reactant 2

HCID 104673212-Trifluoromethylphenoxazine

HCID 203071382-Chloro-1-(1-pyrrolin-2-yl) 2-pyrroline hydrochloride

Product 1

HCID 127993982-Trifluoromethyl-10-[1-(1-pyrrolin-2-YL)-2-pyrrolin-2-YL]phenoxazine

Procedure

Reaction of 2-trifluoromethylphenoxazine with 2-chloro-1-(1-pyrrolin-2-yl)pyrroline hydrochloride according to the procedure of Example 7 affords the free base, 2-TRIFLUOROMETHYL-10-[1-(1-PYRROLIN-2-YL)-2-PYRROLIN-2YL]PHENOXAZINE, m.p. 140°-142° C., from n-hexane. Conversion of the free base affords 2-TRIFLUOROMETHYL-10-[1-(1-PYRROLIN-2-YL)2-PYRROLIN-2-YL]PHENOXAZINE HYDROCHLORIDE HYDRATE, m.p. 222.5°-229° C. (dec.)(corr.).

Sources & evidence

ORD record: ord-aa5a72cd6ba8473e8a3e61a0d7da9eb9
Source dataset: uspto-grants-1978_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04115571

Reaction notes

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