HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 5-Ethyl-2-(2-nitroanilino)thiophene-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 5-ethyl-2-(2-nitroanilino)-thiophene-3-carboxylate | HCID 12442327 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Ethyl-2-(2-nitroanilino)thiophene-3-carboxylic acid | HCID 12438960 | — |
Reaction Steps
Ethyl 5-ethyl-2-(2-nitroanilino)-thiophene-3-carboxylate (6.0 g) dissolved in ethanol (100 ml) and water (50 ml) and heated to 60° C. with stirring. Sodium hydroxide (5N, 50 ml) was then added and the temperature maintained for 16 hours. The reaction mixture was cooled and diluted with water (500 ml), and solid title product filtered off, m.p. 189°-191° C. (EtOAc).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04115568 |
| Source dataset | uspto-grants-1978_09 |
| ORD ID | ord-ed0715b0c9c1455fa013dbbe66580853 |
| Source note | uspto-grants-1978_09 |