Ammonium Chloride → HCID 20387717, compound

HRID 1764249Notes

Reaction equation

HRID 1764249 reaction equation
[Br:1][C:2]1[CH:20]=[CH:19][C:5]([NH:6][C:7]2[S:8][C:9]([CH2:17][CH3:18])=[CH:10][C:11]=2[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[C:4]([N+:21]([O-])=O)[CH:3]=1.[Cl-].[NH4+]>O.[Zn]>[NH2:21][C:4]1[CH:3]=[C:2]([Br:1])[CH:20]=[CH:19][C:5]=1[NH:6][C:7]1[S:8][C:9]([CH2:17][CH3:18])=[CH:10][C:11]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13]

Participants

5

Reactant 2

HCID 25517Ammonium ChlorideHCID 20387639HCID 20387639, compound

Product 1

HCID 20387717HCID 20387717, compound

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

Ethyl 2-(4-bromo-2-nitroanilino)-5-ethyl-thiophene-3-carboxylate (0.4 g, (0.001 mol) was added to powdered zinc (0.4 g) and ammonium chloride (0.4 g) in water (10 ml) and stirred at 50° C. for 24 hours. The reaction mixture was filtered and the recovered solid washed successively with water and ethyl acetate. The organic phase was separated, washed with water, dried (MgSO4) and evaporated in vacuo to give the title compound.

Workup

  1. filtrationThe reaction mixture was filtered
  2. washthe recovered solid washed successively with water and ethyl acetate
  3. customThe organic phase was separated
  4. washwashed with water
  5. dry with materialdried (MgSO4)
  6. customevaporated in vacuo

Sources & evidence

ORD record
ord-28f13473878d4f3aa937ab1aaa509acf
Source dataset
uspto-grants-1978_09
Patent number
US04115568

Reaction notes

Loading…