4-Piperidone hydrochloride → HCID 20304777, compound

HRID 1764260Notes

Reaction equation

HRID 1764260 reaction equation
O1C2C=CC=[CH:11][C:6]=2[CH:5]=[CH:4][CH:3]=[N:2]1.[Cl:12][C:13]1[CH:14]=[CH:15][C:16]2[N:22](N=O)[CH2:21][CH2:20][O:19][CH2:18][C:17]=2[CH:25]=1.Cl.N1CCC(=O)CC1>>[ClH:12].[Cl:12][C:13]1[CH:14]=[C:15]2[C:4]3[CH2:3][NH:2][CH2:11][CH2:6][C:5]=3[N:22]3[C:16]2=[C:17]([CH:25]=1)[CH2:18][O:19][CH2:20][CH2:21]3

Participants

4

Reactant 3

HCID 30848514-Piperidone hydrochlorideHCID 17900740HCID 17900740, compoundHCID 20304632HCID 20304632, compound

Product 1

HCID 20304777HCID 20304777, compound

Procedure

By the procedure described in Example 1, the appropriate benzoxazepine is converted to 7-chloro-1,2,3,5-tetrahydro-1-nitroso-4,1-benzoxazepine, m.p. 54°-56°. The latter is reduced to the corresponding 1-amino derivative hydrochloride, which is reacted with 4-piperidone hydrochloride to yield the title compound, m.p. 304°-305°.

Sources & evidence

ORD record
ord-8f15fc4f7d9c4b88a214b079d8844da9
Source dataset
uspto-grants-1978_09
Patent number
US04115577

Reaction notes

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