4-Piperidone hydrochloride → HCID 20304748, compound

HRID 1764261Notes

Reaction equation

HRID 1764261 reaction equation
O1C2C=CC=[CH:11][C:6]=2[CH:5]=[CH:4][CH:3]=[N:2]1.[ClH:12].N[N:14]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[CH:18]([CH3:25])[O:17][CH2:16][CH2:15]1.Cl.N1CCC(=O)CC1>>[ClH:12].[CH3:25][CH:18]1[C:19]2[CH:24]=[CH:23][CH:22]=[C:21]3[C:4]4[CH2:3][NH:2][CH2:11][CH2:6][C:5]=4[N:14]([C:20]=23)[CH2:15][CH2:16][O:17]1

Participants

4

Reactant 3

HCID 30848514-Piperidone hydrochlorideHCID 17900740HCID 17900740, compoundHCID 20304715HCID 20304715, compound

Product 1

HCID 20304748HCID 20304748, compound

Procedure

According to the procedure described in Example 1, the appropriate benzoxazepine is converted to 1-amino-1,2,3,5-tetrahydro- 5-methyl-4,1-benzoxazepine hydrochloride, m.p. 198°-200°, which is reacted with 4-piperidone hydrochloride to yield the title compound, m.p. 285°-286° (dec.).

Sources & evidence

ORD record
ord-4fa0f613801b42d896b8d610a23cbc08
Source dataset
uspto-grants-1978_09
Patent number
US04115577

Reaction notes

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