HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 5-ethyl-2-(2-nitroanilino)-thiophene-3-carboxylate → Ethyl 2-(2-aminoanilino)-5-ethyl-thiophene-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 5-ethyl-2-(2-nitroanilino)-thiophene-3-carboxylate | HCID 12442327 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 2-(2-aminoanilino)-5-ethyl-thiophene-3-carboxylate | HCID 12442333 | — |
Reaction Steps
Ethyl 5-ethyl-2-(2-nitroanilino)-thiophene-3-carboxylate (20.7 g) in ethanol (150 ml) was catalytically reduced over 10% palladium on charcoal (2.0 g) at 60 p.s.i. The catalyst was removed by filtration and the solvent removed by distillation in vacuo. The title product so obtained had a melting point of 50°-52° C. (hexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04115574 |
| Source dataset | uspto-grants-1978_09 |
| ORD ID | ord-932fde9c1e6a4a9888f3a6e8d87de4d9 |
| Source note | uspto-grants-1978_09 |