Ammonium Chloride → HCID 20387717, compound

HRID 1764286Notes

Reaction equation

HRID 1764286 reaction equation
[Br:1][C:2]1[CH:20]=[CH:19][C:5]([NH:6][C:7]2[S:8][C:9]([CH2:17][CH3:18])=[CH:10][C:11]=2[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[C:4]([N+:21]([O-])=O)[CH:3]=1.[Cl-].[NH4+]>O.[Zn]>[NH2:21][C:4]1[CH:3]=[C:2]([Br:1])[CH:20]=[CH:19][C:5]=1[NH:6][C:7]1[S:8][C:9]([CH2:17][CH3:18])=[CH:10][C:11]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13]

Participants

5

Reactant 2

HCID 25517Ammonium ChlorideHCID 20387639HCID 20387639, compound

Product 1

HCID 20387717HCID 20387717, compound

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

Ethyl 2-(4-bromo-2-nitroanilino)-5-ethyl-thiophene-3-carboxylate (0.4 g, 0.001 mol) was added to powdered zinc (0.4 g) and ammonium chloride (0.4 g) in water (10 ml) and stirred at 50° C. for 24 hours. The reaction mixture was filtered and the recovered solid washed successively with water and ethyl acetate. The organic phase was separated, washed with water, dried (MgSO4) and evaporated in vacuo to give the title compound.

Workup

  1. filtrationThe reaction mixture was filtered
  2. washthe recovered solid washed successively with water and ethyl acetate
  3. customThe organic phase was separated
  4. washwashed with water
  5. dry with materialdried (MgSO4)
  6. customevaporated in vacuo

Sources & evidence

ORD record
ord-d3b64ad456bd439486ae74427c23bef7
Source dataset
uspto-grants-1978_09
Patent number
US04115574

Reaction notes

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