Oxygen → HCID 12806329, compound

Participants

Reaction Steps

20 g. of 1-β-D-ribofuranosyl-imidazole-4,5-dicarboxamide [see, for example, J. Chem. Soc. 1949, 232] are dissolved in 2 litres of water at 80° C. Platinum (obtained by hydrogenating 10 g. of platinum oxide) is added. Oxygen is blown into the suspension with vigorous stirring. The temperature is held at 80° C. 8.6 G. of sodium hydrogen carbonate are added in several portions so that the mixture always remains alkaline. After 2 days, the catalyst is filtered off, the filtrate concentrated to 100 ml. and acidified with trifluoroacetic acid while cooling with ice-water. The crystallizing solution is left to stand overnight in a refrigerator and the product is then filtered off. 12.4 G. of 1-desoxy-1-(4,5-dicarbamoylimidazol-1-yl)-β-D-ribofuranuronic acid are obtained.

Provenance & Evidence