Formic Acid → HCID 15052523, compound

HRID 1764409Notes

Reaction equation

HRID 1764409 reaction equation
[NH2:1][C:2]1[CH:6]=[C:5]([CH3:7])[O:4][N:3]=1.[CH:8](O)=[O:9]>>[CH:8]([NH:1][C:2]1[CH:6]=[C:5]([CH3:7])[O:4][N:3]=1)=[O:9]

Participants

3

Reactant 2

HCID 284Formic AcidHCID 661723-Amino-5-methylisoxazole

Product 1

HCID 15052523HCID 15052523, compoundYield 93.8%

Procedure

To 3-amino-5-methylisoxazole (10.0 g), 99% formic acid (47.0 g) is added, and the resultant mixture is refluxed for 1 hour with stirring. The reaction mixture is evaporated under reduced pressure to remove the formic acid. The residue is mixed with icy water (50 ml), and the precipitated crystals are filtered. The crystals are washed with water and dried under reduced pressure to give 3-formylamino-5-methylisoxazole (12.06 g). This substance is recrystallized from methanol to give crystals melting at 130.5° to 131° C.

Workup

  1. customThe reaction mixture is evaporated under reduced pressure
  2. customto remove the formic acid
  3. additionThe residue is mixed with icy water (50 ml)
  4. filtrationthe precipitated crystals are filtered
  5. washThe crystals are washed with water
  6. customdried under reduced pressure

Sources & evidence

ORD record
ord-24775bb8335546e48b9754811924cab8
Source dataset
uspto-grants-1978_09
Patent number
US04116671

Reaction notes

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