Acetic Anhydride → HCID 22768161, compound

HRID 1764410Notes

Reaction equation

HRID 1764410 reaction equation
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[O:4][N:3]=1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>O>[C:11]([NH:1][C:2]1[CH:6]=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[O:4][N:3]=1)(=[O:13])[CH3:12]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 1714733-Isoxazolamine, 5-(1,1-dimethylethyl)-

Product 1

HCID 22768161HCID 22768161, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 3-amino-5-t-butylisoxazole (2.80 g), acetic anhydride (6 ml) is added, and the resultant mixture is allowed to stand at room temperature for 4 hours. The reaction mixture is mixed with chilled water (50 ml), and the precipitated crystals are filtered. The crystals are washed with water and dried to give 3-acetylamino-5-t-butylisoxazole (3.39 g). This substance is recrystallized from hexane to give crystals melting at 120.5° to 121.0° C.

Workup

  1. filtrationthe precipitated crystals are filtered
  2. washThe crystals are washed with water
  3. customdried

Sources & evidence

ORD record
ord-18f9c845352847d7a0ee6179ff8e4f31
Source dataset
uspto-grants-1978_09
Patent number
US04116671

Reaction notes

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