2,6-Dimethoxyphenol → HCID 13112725, compound

HRID 1764444Notes

Reaction equation

HRID 1764444 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[OH:11].[NH2:12][C:13]1[N:18]=[C:17]([NH2:19])[C:16]([CH2:20]C2C=C(OC)C(O)=C(OC)C=2)=[CH:15][N:14]=1>>[NH2:12][C:13]1[N:18]=[C:17]([NH2:19])[C:16]([CH2:20][C:8]2[CH:7]=[CH:6][C:5]([O:9][CH3:10])=[C:4]([OH:11])[C:3]=2[O:2][CH3:1])=[CH:15][N:14]=1

Participants

3

Reactant 2

HCID 70412,6-DimethoxyphenolHCID 104235704-((2,4-Diamino-5-pyrimidinyl)methyl)-2,6-dimethoxyphenol

Product 1

HCID 13112725HCID 13112725, compound

Procedure

The procedure of Example 1 was repeated using 2,6-dimethoxyphenol in place of the 2,6-diethylphenol. A good yield of a mixture of 2,4-diamino-5-(3,5-dimethoxy-4-hydroxybenzyl)pyrimidine and 2,4-diamino-5-(2,4-dimethoxy-3-hydroxybenzyl)pyrimidine was obtained. These components of the mixture could be separated by fractional crystallisation. The latter melting at between 246° and 248° C. (free base).

Sources & evidence

ORD record
ord-58792c27f3c745fb8dd04094a82216eb
Source dataset
uspto-grants-1978_09
Patent number
US04116958

Reaction notes

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