反应详情

The procedure of Example 1 was repeated using 2,6-dimethoxyphenol in place of the 2,6-diethylphenol. A good yield of a mixture of 2,4-diamino-5-(3,5-dimethoxy-4-hydroxybenzyl)pyrimidine and 2,4-diamino-5-(2,4-dimethoxy-3-hydroxybenzyl)pyrimidine was obtained. These components of the mixture could be separated by fractional crystallisation. The latter melting at between 246° and 248° C. (free base).