Hydrochloric Acid → HCID 22768519, compound

Participants

Reaction Steps

00.2 mole of the 4-(1,3-dioxo-hexahydro-2-isoindolinyl)phenylacetic acid thus obtained was dissolved in 20 ml of dimethyl sulphoxide. The resulting mixture was reduced with 1.14 g (0.03 mole) of sodium borohydride, as described in step (b) of Example 1, and was then poured into ice-water. The mixture was acidified with dilute hydrochloric acid, to precipitate crystals. These crystals were collected by filtration, dried and recrystallized from a mixture of ethanol and petroleum ether, giving 5.0 g (86.2%) of 4-(3-hydroxy-1-oxo-hexahydro-2-isoindolinyl)phenylacetic acid, decomposing at 145° C.

Provenance & Evidence