Sodium Hydroxide → Aluminium alpha-[4-(1-oxo-4,7-dihydro-2-isoindolinyl)phenyl]propionate

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Reaction Steps

A mixture of 0.5 g (0.0018 mole) of α-[4-(1-oxo-4,7-dihydro-2-isoindolinyl)phenyl]propionic acid, 0.072 g (0.0018 mole) of sodium hydroxide and 5 ml of water was stirred for about 1 hour. At the end of this time, a solution of 0.434 g (0.0018 mole) of aluminium chloride hexahydrate in 10 ml of water was added dropwise at room temperature to the mixture. The white precipitate produced was collected by filtration, washed with 75 ml of water and dried at 105° C. for 4 hours. There was obtained 0.45 g of a white solid, which was sparingly soluble in most organic solvents and slightly soluble in dimethyl sulphoxide, and which had a melting point over 300° C.

Provenance & Evidence