1-BOC-4-[2-(4-amino-3-butylamino-phenoxy)-ethyl]-piperazine → 1-butyl-2-(4-[2-(4-chlorophenyl)ethoxy]-phenyl)-6-(2-piperazin-1-yl-ethoxy)-1H-benzimidazole

Participants

Reaction Steps

A mixture of 4-[2-(4-chloro-phenyl)-ethoxy]-benzaldehyde (0.08 g)and 1-BOC-4-[2-(4-amino-3-butylamino-phenoxy)-ethyl]-piperazine (0.10 g) was subjected to General Procedure K. Ethanol was removed in vacuo and the residue purified on silica gel with 1-2% MeOH/DCM. The BOC-group was removed employing General Procedure T1 to give 1-butyl-2-{4-[2-(4-chlorophenyl)ethoxy]-phenyl}-6-(2-piperazin-1-yl-ethoxy)-1H-benzimidazole (0.081 g).

Provenance & Evidence