Methanol → HCID 22768408, compound

Participants

Reaction Steps

To a suspension of 3 parts of 2-amino-7-chloro-5-(p-methoxyphenyl)-3H-1,4-benzodiazepine in a mixture of 50 parts by volume of methanol and 0.6 part by volume of glacial acetic acid is added dropwise with stirring 1.5 parts by volume of 100% hydrazine hydrate. The mixture is stirred for 30 minutes and poured into ice water, followed by extraction with chloroform. The chloroform layer is washed with water, dried over sodium sulfate and the solvent is evaporated. Treatment of the residue with benzene yields 7-chloro-2-hydrazino-5-(p-methoxypheyl)-3H-1,4-benzodiazepine as colorless crystals melting at 214° C to 220° C.

Provenance & Evidence