Ethanol → 2-hydrazino-5-phenyl-3H-1,4-benzodiazepine

Participants

Reaction Steps

To a mixture of 2.35 parts of 2-amino-5-phenyl-3H-1,4-benzodiazepine, 50 parts by volume of ethanol and 1.2 parts by volume of glacial acetic acid is added 1.5 parts by volume of 100% hydrazine hydrate and the mixture is stirred for 1 hour at room temperature. Treatment of the mixture in a similar manner to Example 2 yields 2-hydrazino-5-phenyl-3H-1,4-benzodiazepine as white crystals. Recrystallization from a mixture of methylene chloride and benzene yields white crystals melting at 116° to 118° C. (effervescence).

Provenance & Evidence