Sulfuric Acid → 8-chloro-1-ethyl-6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepine

関与物質

反応手順

To a mixture of 1.4 parts of 7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine prepared in Example 1, 50 parts by volume of ethanol and 4 parts by volume of ethyl orthopropionate is added 0.5 part by volume of concentrated sulfuric acid. The mixture is stirred for 30 minutes at room temperature and then treated in a similar manner to Example 14, whereby 8-chloro-1-ethyl-6-phenyl-4H-s-triazolo- [4,3-a] [1,4] benzodiazepine is yielded as crystals. Recrystallization from acetone yields colorless prisms melting at 229° C to 230° C.

情報源と証拠