Chloroform → HCID 22768400, compound

Participants

Reaction Steps

To a mixture of 2.85 parts of 7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine, 50 parts by volume of chloroform and 2 parts by volume of triethylamine, a solution of 1.6 parts of enanthylchloride in 20 parts by volume of diethyl ether is gradually added with ice-cooling. The mixture is stirred for a while to complete the reaction. After evaporation of the solvent under reduced pressure, the residue is treated with methanol to yield 7-chloro-2-(2-enanthylhydrazino)-5-phenyl-3H-1,4-benzodiazepine as crystals. Recrystallization from a mixture of dimethylformamide and water yields colorless needles melting at 205° C to 206° C (effervescence).

Provenance & Evidence