HCID 22768400, compound → HCID 86736039, compound

HRID 1764525Notes

Reaction equation

HRID 1764525 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][NH:13][C:14](=O)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[CH2:9][N:8]=[C:7]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:6]=2[CH:28]=1>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:14]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[N:13][N:12]=[C:10]3[CH2:9][N:8]=[C:7]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:6]=2[CH:28]=1

Participants

3

Reactant 1

HCID 22768400HCID 22768400, compound

Product 1

HCID 86736039HCID 86736039, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A suspension of 4 parts of 7-chloro-2-(2-enanthylhydrazino)-5-phenyl-3H-1,4-benzodiazepine prepared in Example 31 in 20 parts by volume of pyridine is refluxed for about 3 hours. After evaporation of pyridine, water is added to the residue, whereby 8-chloro-1-hexyl-6-phenyl-4H-s-triazolo [4,3-a] [1,4] benzodiazepine is yielded as crystals. Recrystallization from aqueous acetone yields colorless flakes melting at 75° C to 78° C (sintering).

Workup

  1. temperatureis refluxed for about 3 hours
  2. customAfter evaporation of pyridine, water
  3. additionis added to the residue

Sources & evidence

ORD record
ord-3c093fba0f33433883770b32f9f75d8a
Source dataset
uspto-grants-1978_09
Patent number
US04116956

Reaction notes

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