Benzoyl chloride → HCID 22768412, compound

Participants

Reaction Steps

To a solution of 1.4 parts of 7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine, prepared in Example 1, in 25 parts by volume of tetrahydrofuran is added 0.62 part by volume of benzoyl chloride, and the mixture is stirred at room temperature for 2 hours to complete the reaction. The reaction mixture is neutralized with a saturated aqueous solution of sodium bicarbonate. The resulting white precipitate is separated, washed with water and then with methanol, and dried, whereby 2-(2-benzoylhydrazino)-7-chloro-5-phenyl-3H-1,4-benzodiazepine is yielded as crystals. Recrystallization from a mixture of chloroform and methanol yields white needles melting at 207° C to 208° C (effervescence).

Provenance & Evidence