Diethyl Ether → HCID 22768403, compound

Participants

Reaction Steps

In a similar manner to Example 31, a solution of 0.85 part of phenylacetyl chloride in 10 parts by volume of diethyl ether is added to a mixture of 1.4 parts of 7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine, 1 part by volume of triethylamine and 25 parts by volume of chloroform. The whole mixture is stirred for 45 minutes, whereby 7-chloro-2-(2-phenylacetylhydrazino)-5-phenyl-3H-1,4-benzodiazepine is yielded as crystals. Recrystallization from a mixture of dimethylformamide and water yields colorless fine prisms melting at 220° C to 221° C (effervescence).

Provenance & Evidence