Sodium borohydride → HCID 20285713, compound

HRID 1764589Notes

Reaction equation

HRID 1764589 reaction equation
[CH3:1][C:2]1[S:3][C:4]([S:10][CH3:11])=[C:5]([CH3:9])[C:6]=1[CH:7]=[O:8].[BH4-].[Na+]>C(O)C>[CH3:1][C:2]1[S:3][C:4]([S:10][CH3:11])=[C:5]([CH3:9])[C:6]=1[CH2:7][OH:8]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 20285662HCID 20285662, compound

Product 1

HCID 20285713HCID 20285713, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

15.0 G. of 2,4-dimethyl-5-(methylthio)thiophene-3-carboxaldehyde was dissolved in 150 ml. of dry ethanol with stirring at 20° C. 0.8 G. of sodium borohydride was added and the mixture was stirred for 30 minutes, then poured into ice water and extracted with ethyl ether. The combined ether extracts were washed with a solution of 5% sodium carbonate and saturated sodium chloride solution, dried over sodium sulfate, filtered, and evaporated to yield 2,4-dimethyl-3-hydroxymethyl-5-(methylthio)thiophene.

Workup

  1. extractionextracted with ethyl ether
  2. washThe combined ether extracts were washed with a solution of 5% sodium carbonate and saturated sodium chloride solution
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-61b81288a7f1457880e4a841efc915b4
Source dataset
uspto-grants-1978_09
Patent number
US04116975

Reaction notes

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