Acetic acid, 2-phenoxy-, ethyl ester → Ethyl phenylacetate

HRID 1764596Notes

Reaction equation

HRID 1764596 reaction equation
Cl[C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)OCC(OCC)=O.ClC1C=CC=CC=1O[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21].O(CC(OCC)=O)C1C=CC=CC=1>>[C:2]1([CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH:3]=[CH:4][CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 3

HCID 17365Acetic acid, 2-phenoxy-, ethyl esterHCID 302826Ethyl 2-(2-chlorophenoxy)acetateHCID 735422Ethyl 2-(3-chlorophenoxy)acetate

Product 1

HCID 7590Ethyl phenylacetate

Procedure

Following Example 15 but using ethyl 3-chlorophenoxyacetate, ethyl 2-chlorophenoxyacetate or ethyl phenoxyacetate, respectively, in place of ethyl phenylacetate, the final compounds obtained were the PGE2 analogs of Example 15 wherein R (of structure IV) is 3-chlorophenoxymethyl, 2-chlorophenoxymethyl or phenoxymethyl.

Sources & evidence

ORD record
ord-38eda58753a14464a05450193e27edd0
Source dataset
uspto-grants-1978_09
Patent number
US04117014

Reaction notes

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