HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 20381756, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Methyl 3-(2-nitrophenoxy)-1H-indole-2-carboxylate | HCID 54304514 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | HCID 20381756 | HCID 20381756 | — |
Reaction Steps
6.73g (0.16 mole) of 57% sodium hydride in mineral oil was washed with hexane and suspended in 500ml of THF. To this was added 43.4g (0.139 mole) of methyl-3-[o-nitrophenoxy]-indole-2-carboxylate. The mixture was stirred at reflux for 1 hour, then 42.6g (0.3 mole) of methyl iodide was added and reflux continued for 3 hours. Water (5ml) was added, the THF removed by distillation and the gummy residue recrystallized from isopropanol to give analytical material as yellow needles, mp. 119°-121°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04117129 |
| Source dataset | uspto-grants-1978_09 |
| ORD ID | ord-79f5d45a4e6e482992c0d9434888014e |
| Source note | uspto-grants-1978_09 |