反应详情

A mixture comprising 2.28 g. of 7-methyl-6-(m-nitrophenyl)-1,2,4-triazolo[4,3-b]pyridazine (prepared as described in Example 4), 100 ml. of ethyl alcohol and a catalytic amount of platinum oxide is shaken in a Parr shaker under 40 pounds of hydrogen pressure for 11/2 hours. The reaction mixture is filtered free of catalyst and the filtrate is concentrated to afford the product of the example as a yellow solid, m.p. 182°-186° C.

1. filtrationThe reaction mixture is filtered free of catalyst
2. concentrationthe filtrate is concentrated
3. customto afford the product of the example as a yellow solid, m.p. 182°-186° C.