HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 3-(p-Bromophenyl)-6-chloro-4-methylpyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 6-(p-bromophenyl)-5-methyl-3(2H)-pyridazinone | HCID 23333668 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(p-Bromophenyl)-6-chloro-4-methylpyridazine | HCID 20398289 | — |
Reaction Steps
A 10.0 g. portion of 6-(p-bromophenyl)-5-methyl-3(2H)-pyridazinone [Journal of Medicinal Chemistry 17, 281 (1974)] and 100 ml. of phosphorus oxychloride is heated at steam bath temperature for 3 hours. The mixture is added dropwise to cold water while stirring. The resulting solid is filtered and washed with water to afford 3-(p-bromophenyl)-6-chloro-4-methylpyridazine as a grey solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04117130 |
| Source dataset | uspto-grants-1978_09 |
| ORD ID | ord-6a7b073ef9524a0c83773fa5ff8cfc64 |
| Source note | uspto-grants-1978_09 |