HCID 22768937, compound → HCID 22768944, compound

HRID 1764651Notes

Reaction equation

HRID 1764651 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[N:13][C:14](Cl)=[CH:15][CH:16]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>C(O)CCC>[CH3:8][C:11]1[N:13]2[N:12]=[C:11]([C:8]3[CH:9]=[CH:10][C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:6][CH:7]=3)[CH:16]=[CH:15][C:14]2=[N:13][N:12]=1

Participants

3

Reactant 1

HCID 22768937HCID 22768937, compound

Product 1

HCID 22768944HCID 22768944, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 5.0 g. of 3-(p-tert-butylphenyl)-6-chloropyridazine, 3.13 g. of acetylhydrazide and 50 ml. of n-butanol is refluxed for 48 hours. The mixture is concentrated under vacuum and the residue stirred with 100 ml. of water and 100 ml. of ether. The mixture is filtered to give 3.0 g. of tan solid, m.p. 144°-146° C. Recrystallization from acetone/hexane gives the product as pale yellow crystals, m.p. 142°-145° C.

Workup

  1. additionA mixture of 5.0 g
  2. concentrationThe mixture is concentrated under vacuum
  3. filtrationThe mixture is filtered
  4. customto give 3.0 g
  5. customRecrystallization from acetone/hexane

Sources & evidence

ORD record
ord-0f9e301876bc4a37aab34026242f06e7
Source dataset
uspto-grants-1978_09
Patent number
US04117130

Reaction notes

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